Urodele amphibians, for example the axolotl, have single Mix




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steriods Mice and humans have only single Mix and Nodal genes, meaning that the Xenopus GRN is overly complex compared with higher vertebrates. Urodele amphibians steroid, for example the axolotl, have single Mix and Nodal genes required for mesoderm and endoderm formation giving a model organism for the study of a simplified mesendoderm GRN.We study the axolotl mesendoderm GRN by developing mathematical models that encompass the time evolution of transcription factors in a cell. A detailed investigation reveals that, despite differences in the axolotl mesendoderm GRN compared with the Xenopus, the model can qualitatively reproduce experimental observations. steriods

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